We are seeking an experienced and motivated Clinical Operations Lead to join our drug development team, focusing on early-stage clinical development of biologic drugs in oncology and inflammatory diseases.
\nAs the Director and Lead of Clinical Operations, you will oversee the design, execution, and management of clinical trials, ensuring alignment with corporate objectives and regulatory requirements. You will lead a high-performing clinical operations function, develop strategies to accelerate development timelines, and establish best practices for trial execution.
\nThe salary estimated for this position is $275,000 - $295,000 + bonus + options + benefits. Compensation will vary depending on job-related knowledge, skills, and experience. Actual compensation will be confirmed in writing at the time of the offer.
\nWhat BigHat Offers:
\nBigHat Biosciences is seeking a self-motivated individual for a Research Associate I, Platform Reagents & Assay Support (PRAS), role to power its in-house reagent manufacturing and QC efforts.
\nBigHat Biosciences is looking for a Senior Software Engineer to join their engineering team. This role involves owning a significant area of their platform, leading epics end-to-end, and shaping the architecture and engineering practices.
\nThe ideal candidate will have 7+ years of professional software engineering experience building and owning production systems, or 5+ years of experience with prior experience in biotech, life sciences, laboratory environments, or scientific software.
\nKey Responsibilities:
\nBenefits:
\nBigHat Biosciences is seeking a self-motivated individual for a Research Associate, CFPS Production role to manufacture, validate and execute experiments to develop cell-free protein synthesis (CFPS) reagents for BigHat’s high-throughput, automated platform for producing and characterizing antibodies.
\nThe salary estimated for this position is $75,000 - $88,000 + bonus + options + benefits. Compensation will vary depending on job-related knowledge, skills, and experience. Actual compensation will be confirmed in writing at the time of the offer.
\nWhat BigHat Offers:
\nBigHat Biosciences is seeking a hands-on Scientist II, Developability to drive antibody developability assessments. You will spend most of your time at the bench executing and innovating on developability workflows.
\nThe role: We are seeking a curious and motivated Associate Scientist to join the Display Technologies team. This individual will contribute to our antibody discovery and engineering efforts and help generate high-quality data to improve our machine learning models using display technologies, working closely with senior scientists and cross-functional teams.
\nKey Responsibilities:
\nSupport R&D projects advancing display technologies at BigHat that expands our antibody discovery capabilities and feed our ML models.
\nLead in the construction and QC of phage and yeast display libraries across diverse antibody formats (VHH, scFv, Fab) using standard molecular biology techniques (PCR, molecular cloning, electroporation).
\nExecute phage and yeast display selections using naive and affinity and stability maturation libraries to discover and engineer antibodies with desired therapeutic properties.
\nExpress, purify, and characterize display-derived molecules using assays including ELISA, flow cytometry, BLI/SPR, CE-SDS, and others.
\nAnalyse selection results and contribute to discussions on next steps and future experimental design.
\nCollaborate with our Data Science and Machine Learning teams to inform library design and interpret selection data for model training.
\nPresent experimental plans and results during regular meetings with manager and science teams.
\nMaintain thorough records using LIMS and electronic notebooks.
\nBenefits: The salary estimated for this position is $120,000 - $135,000 + bonus + options + benefits. Compensation will vary depending on job-related knowledge, skills, and experience. Actual compensation will be confirmed in writing at the time of the offer.
\nWhat BigHat Offers:
\nRange of health insurance plan options through Anthem and Kaiser (monthly credit if benefit waived)
\nDental, and vision coverage through Guardian
\nAdditional well-being benefits through Nayya, OneMedical, Wagmo, Rula, and more
\n401(k) with company match
\nDTO, two weeks of company-wide shutdown, and 12 company holidays
\nPaid parental leave
","enriched_at":1781118554574},{"id":"job_b581ff3b-f6c","title":"Scientist II, Cell Line Engineering","source_url":"https://bighatbiosciences.pinpointhq.com/en/postings/c8185f0d-3d1e-4bdf-8bf6-53ac0517adae","location":"San Mateo, CA","job_type":"full time","experience_level":"senior","work_arrangement":"onsite","category":"Engineering","description":"The role: BigHat is looking for an energetic and motivated individual to lead cell line engineering as a core Platform capability in support of our pipeline Discovery and early R&D efforts.
\nThis is a lab-based role that will report directly to the Head of Protein Sciences, work cross-functionally with Programs and Discovery, and directly impact the identification and validation of next-generation biotherapeutics engineered on the Milliner Platform.
\nOnboard all the core components necessary for engineering cell lines for expressing pipeline targets including expression vectors, gene delivery methods, selective antibiotic concentration determination protocols, expression validation and cell sorting capabilities.
\nCulture and maintain a variety of cell types; generate diverse target cell lines including knock-outs, stable cell lines overexpressing one or more targets, and reporter cell lines.
\nPerform the validation of cell line expression using flow and sequencing (Sanger or NGS) based methods.
\nGenerate bulk pool and single cell populations utilizing FACS to select for cell lines of various expression levels.
\nMaintain an organized cell line inventory with all relevant documentation.
\nInvestigate target expression biology to recapitulate the most native conditions for expression.
\nWork with end-user stakeholders to confirm correct domain expression and associated sequences.
\nIn collaboration with end-user stakeholders, establish the workflows, timelines, and deliverables for cell line engineering from request to hand-off.
\nCollaborate with automation engineers to automate routine cell culture workflows to increase efficiencies and throughput.
\nBenefits: The salary estimated for this position is $145,000 - $165,000 + bonus + options + benefits.
\nWhat BigHat Offers:
\nRange of health insurance plan options through Anthem and Kaiser (monthly credit if benefit waived)
\nDental, and vision coverage through Guardian
\nAdditional well-being benefits through Nayya, OneMedical, Wagmo, Rula, and more
\n401(k) with company match
\nDTO, two weeks of company-wide shutdown, and 12 company holidays
\nPaid parental leave
","enriched_at":1780672260322},{"id":"job_417e72af-a08","title":"Senior Research Associate, Discovery Medicine","source_url":"https://bighatbiosciences.pinpointhq.com/en/postings/5a57e4d0-a767-497c-a832-1a7b3f883360","location":"San Mateo, CA","job_type":"full time","experience_level":"senior","work_arrangement":"onsite","category":"Research and Development","description":"The role: We are looking for a motivated and energetic Senior Research Associate with a strong background in Immunology, cell culture, flow cytometry and primary cell-based assays to support the characterization of our lead therapeutic candidates.
\nKey Responsibilities: Drive the development of therapeutics by owning the functional characterization of therapeutic candidates. Plan, execute, and analyze TDCC, T cell activation, cytokine release, FACS, ELISA, ADCC, and other relevant functional assays. Perform isolation and culture of primary immune cells from blood or tissue. Inform program plans based upon experimental results and make relevant recommendations for program conceptualization and advancement. Keep detailed and organized records of experimental protocols and results. Proactively and independently interpret and present scientific findings. Collaborate and communicate across a diverse research team to successfully progress scientific goals.
\nBenefits: The salary estimated for this position is $100,000 - $115,000 + bonus + options + benefits. Compensation will vary depending on job-related knowledge, skills, and experience. Actual compensation will be confirmed in writing at the time of the offer.
\nWhat BigHat Offers: Range of health insurance plan options through Anthem and Kaiser (monthly credit if benefit waived) Dental, and vision coverage through Guardian Additional well-being benefits through Nayya, OneMedical, Wagmo, Rula, and more 401(k) with company match DTO, two weeks of company-wide shutdown, and 12 company holidays Paid parental leave
","enriched_at":1780402248615},{"id":"job_3bf102f8-b63","title":"Associate Director/Principal, Machine Learning Scientist","source_url":"https://bighatbiosciences.pinpointhq.com/en/postings/f4448727-74af-40b7-8c4c-120b5b1a2e25","location":"San Mateo, CA","job_type":"full time","experience_level":"senior","work_arrangement":"hybrid","category":"Engineering","description":"We are seeking a creative and accomplished Associate Director or Principal Machine Learning Scientist to advance the state of the art in ML-driven therapeutic antibody design.
\nOur full-stack antibody drug development platform uses machine learning to drive every stage from discovery to optimization. Our roboticized high-throughput wet-lab continually adds to our large proprietary datasets, which are piped through a custom LIMS++ data management and orchestration layer to automatically update and deploy the latest models.
\nAs a successful candidate, you will apply your world-class machine learning skillset to refine and expand this state-of-the-art protein engineering platform. Success will mean not only hands-on methods development, but helping shape the direction for future machine learning research, and actively participating in the application of our platform to the accelerated design of new therapeutics.
\nThe salary estimated for this position is $254,000 - $290,000 + bonus + options + benefits. Compensation will vary depending on job-related knowledge, skills, and experience. Actual compensation will be confirmed in writing at the time of the offer.
\nWhat BigHat Offers:
\n