{"data":{"company":{"name":"Bighatbiosciences","slug":"bighatbiosciences","logo_url":"https://logos.yubhub.co/bighat.bio.png","canonical_domain":"bighat.bio","editorial":null,"wikidata_id":null,"founded":null,"ceo":null,"founders":[],"hq_location":null,"industry":null,"employee_count":null,"official_website":null,"wikipedia_url":null,"stock_ticker":null,"stock_price":null,"market_cap":null,"revenue":null,"ipo_date":null,"sector":null,"full_time_employees":null,"company_description":null,"twitter_username":null,"linkedin_id":null,"instagram_username":null,"facebook_id":null,"parent_org":null,"country":null,"github_org":null,"github_public_repos":null,"github_followers":null,"github_verified":0,"github_description":null,"github_location":null,"github_blog":null,"github_twitter":null,"stock_exchange":null,"stock_beta":null,"stock_range":null,"stock_is_actively_trading":null,"fmp_image":null,"fmp_address":null,"fmp_city":null,"fmp_state":null,"fmp_country":null,"recent_news":[],"search_interest_index":null,"search_interest_trend":null,"wikipedia_monthly_views":null,"hn_mention_count":null,"hn_top_stories":[],"wayback_first_year":null,"sec_incorporation_state":null,"sec_latest_filing_type":null,"sec_latest_filing_date":null,"sec_filings":[],"research_papers_count":null,"research_citations_count":null,"research_h_index":null,"research_topics":[],"is_federal_contractor":null,"earnings_calendar":[],"industry_canonical":null,"enrichment_sources":[],"last_enriched_at":null},"hiring":{"total_jobs":11,"categories":[{"category":"lab science","count":4},{"category":"it","count":2},{"category":"engineering","count":2},{"category":"research and development","count":1},{"category":"operations","count":1},{"category":"laboratory","count":1}],"experience_levels":[{"level":"senior","count":7},{"level":"entry","count":2},{"level":"mid","count":1},{"level":"executive","count":1}],"work_arrangements":[{"arrangement":"onsite","count":7},{"arrangement":"remote","count":2},{"arrangement":"hybrid","count":2}],"top_titles":[{"title":"SharePoint Consultant","count":1},{"title":"Senior Software Engineer","count":1},{"title":"Senior Scientist I, Antibody Engineering","count":1},{"title":"Senior Research Associate, Discovery Medicine","count":1},{"title":"Senior Director, Clinical Operations","count":1},{"title":"Scientist II, Developability","count":1},{"title":"Research Associate I, Platform Reagents & Assay Support","count":1},{"title":"Research Associate I, CFPS Production","count":1},{"title":"Principal, Machine Learning Scientist","count":1},{"title":"Director, Antibody Discovery","count":1},{"title":"Associate Scientist, Display Technologies","count":1}],"locations":[{"location":"san mateo, ca","count":11}],"skills":[{"skill":"Flow Cytometry","required":2,"preferred":0,"total":2},{"skill":"Automation","required":0,"preferred":2,"total":2},{"skill":"Antibody Biology","required":2,"preferred":0,"total":2},{"skill":"Biochemistry","required":2,"preferred":0,"total":2},{"skill":"Antibody Engineering","required":2,"preferred":0,"total":2},{"skill":"Python","required":2,"preferred":0,"total":2},{"skill":"AWS","required":1,"preferred":1,"total":2},{"skill":"PyTorch","required":2,"preferred":0,"total":2},{"skill":"Protein Engineering","required":2,"preferred":0,"total":2},{"skill":"Immunology","required":1,"preferred":0,"total":1},{"skill":"Cell Culture","required":1,"preferred":0,"total":1},{"skill":"Primary Cell-based Assays","required":1,"preferred":0,"total":1},{"skill":"Therapeutic Candidates","required":1,"preferred":0,"total":1},{"skill":"High-throughput Assays","required":0,"preferred":1,"total":1},{"skill":"Scientific Curiosity","required":0,"preferred":1,"total":1},{"skill":"Problem-solving Abilities","required":0,"preferred":1,"total":1},{"skill":"Molecular Biology","required":1,"preferred":0,"total":1},{"skill":"Display Technologies","required":1,"preferred":0,"total":1},{"skill":"Protein Expression","required":1,"preferred":0,"total":1},{"skill":"Elisa","required":1,"preferred":0,"total":1}],"salary_stats":{"count":10,"min":81500,"q1":107500,"median":172500,"q3":235000,"max":285000},"job_types":[{"type":"full time","count":10},{"type":"contract temp","count":1}],"latest_jobs":[{"id":"job_793d20ac-467","title":"Senior Scientist I, Antibody Engineering","source_url":"https://bighatbiosciences.pinpointhq.com/en/postings/f237fe02-5f68-47bc-8403-ba6502fd88f6","location":"San Mateo, CA","job_type":"full time","experience_level":"senior","work_arrangement":"onsite","category":"Lab Science","description":"<p>BigHat Biosciences is seeking a Senior Scientist I to lead therapeutic programs on the antibody engineering &amp; binder generation team. You will drive antibody discovery, design, optimization, and characterization.</p>\n<h3>Key Responsibilities</h3>\n<ul>\n<li>Lead cross-functional project teams on the execution of rapid, iterative multi-objective optimization to identify high-value therapeutic antibodies.</li>\n<li>Understand target biology to better design antibodies that meet the company&#39;s candidate profile.</li>\n<li>Contribute expertise in antibody engineering approaches to generate and optimize novel antibodies.</li>\n<li>Collaborate with BigHat leadership and cross-functional team members to ensure a tight linkage between strategy, research, and development components.</li>\n<li>Lead in-depth data analysis of each design cycle to better leverage experimental and computational approaches.</li>\n<li>Communicate results to key decision makers, the broader BigHat team, and external partners.</li>\n</ul>\n<h3>Skills, Knowledge &amp; Expertise</h3>\n<ul>\n<li>Ph.D. in biochemistry, structural biology, protein engineering, or related fields.</li>\n<li>5+ years of advanced research experience in an industry setting.</li>\n<li>Hands-on protein engineering expertise, including structure-guided design, affinity maturation, and rational or computational approaches.</li>\n<li>Experience working with diverse antibody formats.</li>\n<li>Expertise in mammalian cell culture, immunoassay, molecular techniques, and protein expression and characterization.</li>\n<li>Exceptional written, verbal, and visual communication skills.</li>\n<li>Scientific track record and publication record.</li>\n<li>Strong data analysis and interpretation skills.</li>\n</ul>\n<h3>Benefits</h3>\n<p>The salary estimated for this position is $160,000 - $185,000 + bonus + options + benefits.</p>","enriched_at":1786676546749},{"id":"job_3498e8e0-0d8","title":"SharePoint Consultant","source_url":"https://bighatbiosciences.pinpointhq.com/en/postings/a80b04dd-8c16-452c-8dbd-a4bc4b249d2b","location":"San Mateo, CA","job_type":"contract temp","experience_level":"senior","work_arrangement":"remote","category":"IT","description":"<p>BigHat Biosciences is looking for an experienced and detail-oriented SharePoint Development Consultant to support the design, build-out, and configuration of SharePoint-based program management infrastructure for their drug development organisation.</p>\n<p>This is a project-based contract engagement, performed remotely through project completion. The consultant will partner directly with the Operations and Program Management teams to build document control workflows, program-facing SharePoint sites, and Power Automate automations that replace manual, email-based document review and adjudication processes.</p>\n<p>The work will have a particular focus on cGXP documents, IND-related workflows, and regulatory submission processes.</p>\n<h3>Key Responsibilities</h3>\n<ul>\n<li>Design and build SharePoint program management landing pages that surface program documentation, risk communications, and action items for cross-functional stakeholders.</li>\n<li>Integrate Smartsheet outputs or data feeds into SharePoint splash pages to support real-time, redundant visibility into program risks and actions.</li>\n<li>Configure document control workflows using SharePoint and Power Automate, including assignment of document authors, reviewers, and adjudicators for IND-related regulatory submissions.</li>\n<li>Build automated review and adjudication routing for IND chapter documents, replacing manual email-based review chains.</li>\n<li>Configure access controls and library permission structures appropriate for a regulated drug development environment.</li>\n<li>Provide SharePoint site administration support , including troubleshooting and user access management , on an as-needed basis throughout the engagement.</li>\n<li>Lead knowledge transfer and handoff to internal stakeholders upon project completion.</li>\n<li>Optionally: assess and recommend opportunities to incorporate Microsoft 365 Copilot or SharePoint AI agent features.</li>\n</ul>\n<h3>Skills, Knowledge &amp; Expertise</h3>\n<ul>\n<li>Demonstrated experience designing and building SharePoint sites for program management use cases, ideally in a biotech, pharma, or regulated health sciences environment.</li>\n<li>Proficiency in Power Automate workflow configuration within SharePoint.</li>\n<li>Hands-on experience with document control systems and regulated document lifecycle management, including IND authoring pipelines or FDA submission workflows.</li>\n<li>Working knowledge of SharePoint access controls, library permissions, and compliance-aware configuration.</li>\n<li>Experience in clinical or drug development operational settings strongly preferred.</li>\n<li>Ability to work independently, manage deliverables across a remote engagement, and communicate clearly with non-technical stakeholders.</li>\n<li>A collaborative, solution-oriented approach and comfort operating in a fast-moving startup environment.</li>\n<li>Must be based in the United States.</li>\n</ul>","enriched_at":1786676533777},{"id":"job_b8be422b-eff","title":"Director, Antibody Discovery","source_url":"https://bighatbiosciences.pinpointhq.com/en/postings/dee556c2-c83c-4e2e-badb-643293e01b46","location":"San Mateo, CA","job_type":"full time","experience_level":"executive","work_arrangement":"onsite","category":"Lab Science","description":"<p>BigHat Biosciences is seeking an exceptional and highly experienced individual for a position as Director of Antibody Discovery. This individual will lead the company&#39;s antibody discovery and display function. They will be responsible for conceiving of and leading multi-year team and technology strategy as well as managing routine operational execution for identification and maturation of high-quality antibodies across antigen types for both BigHat and BigHat-partnered therapeutic research programs.</p>\n<h3>Key Responsibilities</h3>\n<ul>\n<li>Lead BigHat&#39;s antibody discovery and display functions, setting the scientific, technical, and strategic direction.</li>\n<li>Oversee the routine execution of display-based selection campaigns to enhance and diversify affinity, developability, and function across diverse antibody formats and antigen types in support of BigHat and BigHat-partnered therapeutic programs.</li>\n<li>Manage and mentor a team of scientists responsible for antibody library design, generation, screening, selection, and early optimization.</li>\n<li>Shape and expand BigHat&#39;s antibody discovery technologies and capabilities, including new display and selection methods, library design strategies, and technical approaches that leverage and enhance the company&#39;s integrated experimental and computational platform.</li>\n<li>Provide scientific leadership across discovery and early optimization efforts, ensuring antibodies emerging from selections possess strong functional and developability characteristics.</li>\n<li>Work closely with leaders in Protein Sciences, Data Science/Machine Learning, Engineering, and Platform groups to ensure seamless progression from discovery through characterization and optimization.</li>\n<li>Collaborate with biology and therapeutic research leads to ensure display outputs align with and advance program objectives.</li>\n<li>Foster a collaborative and high-performance culture within the discovery organization.</li>\n</ul>\n<h3>Skills, Knowledge &amp; Expertise</h3>\n<ul>\n<li>Ph.D. in molecular biology, biochemistry, protein engineering, or related discipline with 10+ years of experience in antibody discovery and engineering within academia, biotechnology, or pharmaceutical industries.</li>\n<li>5+ years of managerial experience leading scientific teams.</li>\n<li>Strong expertise with protein display systems such as yeast, phage, mammalian, or mRNA display.</li>\n<li>Demonstrated experience with antibody library design, construction, screening, and selection analysis.</li>\n<li>Deep understanding of antibody structure-function relationships and mechanisms of antigen recognition.</li>\n<li>Experience integrating antibody discovery workflows with downstream characterization and developability assessment, including functional screening and biophysical evaluation of antibody candidates.</li>\n<li>Familiarity with computational or ML-enabled approaches to protein design and optimization.</li>\n<li>Experience advancing biologics from early discovery through lead optimization stages.</li>\n<li>Knowledge of diverse antibody modalities including multispecific antibodies, antibody fragments, and other advanced formats.</li>\n<li>Strong leadership skills with experience building and mentoring scientific teams.</li>\n<li>Strategic thinker capable of aligning discovery activities with broader company goals.</li>\n<li>Excellent communication and cross-functional collaboration skills.</li>\n<li>Self-motivated and comfortable working in a fast-paced startup environment.</li>\n<li>Must be willing to work onsite 5 days per week.</li>\n</ul>\n<h3>Benefits</h3>\n<p>The salary estimated for this position is $220,000 - $250,000 + bonus + options + benefits. Compensation will vary depending on job-related knowledge, skills, and experience. Actual compensation will be confirmed in writing at the time of the offer.</p>\n<p>What BigHat Offers:</p>\n<ul>\n<li>Range of health insurance plan options through Anthem and Kaiser (monthly credit if benefit waived).</li>\n<li>Dental, and vision coverage through Guardian.</li>\n<li>Additional well-being benefits through Nayya, OneMedical, Wagmo, Rula, and more.</li>\n<li>401(k) with company match.</li>\n<li>DTO, two weeks of company-wide shutdown, and 12 company holidays.</li>\n<li>Paid parental leave.</li>\n</ul>","enriched_at":1786156399106},{"id":"job_01729f91-8c3","title":"Principal, Machine Learning Scientist","source_url":"https://bighatbiosciences.pinpointhq.com/en/postings/ed9ce18f-e885-4052-8f9a-e10f952a460a","location":"San Mateo, CA","job_type":"full time","experience_level":"senior","work_arrangement":"remote","category":"IT","description":"<p>We are seeking a Principal Machine Learning Scientist to advance the state of the art in ML-driven therapeutic antibody design at BigHat Biosciences.</p>\n<p>Our full-stack antibody drug development platform uses machine learning to drive every stage from discovery to optimization. A roboticized high-throughput wet-lab continually adds to our large proprietary datasets, which are managed and orchestrated through a custom LIMS++ layer to automatically update and deploy the latest models.</p>\n<p>As a Principal Machine Learning Scientist, you will apply your world-class ML skillset to refine and expand this state-of-the-art protein engineering platform. You will help shape the direction for future ML research and participate in applying the platform to accelerate the design of new therapeutics.</p>\n<h3>Key Responsibilities</h3>\n<ul>\n<li>Design and implement next-generation generative models of antibody sequence and structure, and predictive models of antibody properties, trained on proprietary internal datasets.</li>\n<li>Provide leadership, technical guidance, and mentorship to other ML and data science team members.</li>\n<li>Help set the strategy for future ML research, driven by a strong understanding of BigHat programs and operations.</li>\n<li>Develop, refine, and deploy de novo design methods for generating initial hits to challenging targets.</li>\n<li>Develop multi-modality, multi-objective iterative protein sequence optimization approaches for lab-in-the-loop antibody design.</li>\n<li>Maintain an in-depth understanding of the current state-of-the-art in ML-driven protein engineering.</li>\n<li>Share findings at top-tier conferences and publish in leading scientific journals.</li>\n<li>Provide ML expertise and support for ongoing therapeutics programs.</li>\n<li>Collaborate with the engineering team to ensure efficient deployment of models.</li>\n<li>Work closely with an interdisciplinary team to identify inefficiencies and plan ML methods development.</li>\n</ul>\n<h3>Skills, Knowledge &amp; Expertise</h3>\n<ul>\n<li>PhD in ML/CS or hard sciences with 5+ years of experience in developing and applying novel ML methods.</li>\n<li>Publications in major ML conferences and/or leading journals.</li>\n<li>Strong competency in Python, familiarity with PyTorch, and experience with modern software engineering best practices.</li>\n<li>Excellent communication skills and biomedical domain knowledge.</li>\n<li>Experience with de novo design, NGS data, Bayesian optimization, and antibody biology is a plus.</li>\n</ul>\n<h3>Benefits</h3>\n<ul>\n<li>Salary estimated at $254,000 - $290,000 + bonus + options + benefits.</li>\n<li>Range of health insurance plan options.</li>\n<li>Dental and vision coverage.</li>\n<li>Additional well-being benefits.</li>\n<li>401(k) with company match.</li>\n<li>DTO, two weeks of company-wide shutdown, and 12 company holidays.</li>\n<li>Paid parental leave.</li>\n</ul>","enriched_at":1785881647607},{"id":"job_ea6935dc-3e0","title":"Senior Director, Clinical Operations","source_url":"https://bighatbiosciences.pinpointhq.com/en/postings/738f95b8-1977-4087-904e-5b21e60166fc","location":"San Mateo, CA","job_type":"full time","experience_level":"senior","work_arrangement":"hybrid","category":"Operations","description":"<p>We are seeking an experienced and motivated Clinical Operations Lead to join our drug development team, focusing on early-stage clinical development of biologic drugs in oncology and inflammatory diseases.</p>\n<p>As the Director and Lead of Clinical Operations, you will oversee the design, execution, and management of clinical trials, ensuring alignment with corporate objectives and regulatory requirements. You will lead a high-performing clinical operations function, develop strategies to accelerate development timelines, and establish best practices for trial execution.</p>\n<h3>Key Responsibilities</h3>\n<h4>Leadership &amp; Strategy</h4>\n<ul>\n<li>Develop and execute clinical operational strategies to advance biologics for oncology and inflammatory diseases from early-phase trials to regulatory approval.</li>\n<li>Collaborate with cross-functional teams (e.g., R&amp;D, Regulatory, CMC, Translational Biomarkers) to align clinical strategies with overall company goals.</li>\n<li>Provide insights into trial design, site selection, and patient recruitment strategies.</li>\n<li>Serve as a key point of contact for internal and external stakeholders, including investigators, regulators, and partners; prepare for and support regulatory interactions and inspections.</li>\n</ul>\n<h4>Clinical Trial Execution</h4>\n<ul>\n<li>Lead the planning, initiation, and management of clinical trials (Phase I–III), ensuring they are conducted on time, within budget, and in compliance with global regulatory standards (ICH-GCP, FDA, EMA) and company SOPs.</li>\n<li>Oversee vendor selection and management, including CROs, labs, and other external partners; conduct and manage CRO site monitoring activities to ensure protocol adherence and data integrity.</li>\n<li>Monitor trial progress, manage risks, and resolve operational challenges efficiently.</li>\n<li>Oversee clinical site-side sample management, including collection, processing, storage, and shipment of biological samples in alignment with protocol requirements and chain-of-custody standards.</li>\n</ul>\n<h4>Translational Biomarker Support</h4>\n<ul>\n<li>Partner closely with the Translational Biomarker team to ensure clinical operations infrastructure supports biomarker sample collection, handling, and logistics across all trial sites.</li>\n<li>Coordinate with sites and CROs to ensure biomarker sampling plans are implemented correctly and that sample quality and completeness meet program requirements.</li>\n</ul>\n<h4>Data Management and Quality</h4>\n<ul>\n<li>Oversee clinical data management activities, including data completeness, quality review, and timely query resolution to ensure high-quality, audit-ready datasets.</li>\n<li>Implement and maintain data quality management processes in collaboration with data management and biostatistics partners.</li>\n</ul>\n<h4>Clinical Document Generation</h4>\n<ul>\n<li>Coordinate cross-functional input and review cycles to deliver complete, high-quality documentation.</li>\n</ul>\n<h4>Budget and Resource Management</h4>\n<ul>\n<li>Develop and manage clinical operations budgets, ensuring cost-effective resource allocation.</li>\n<li>Optimize timelines and resources to meet critical milestones and deliverables.</li>\n</ul>\n<h3>Skills, Knowledge &amp; Expertise</h3>\n<ul>\n<li>Advanced degree in life sciences, pharmacy, or a related field (PhD, MD, PharmD preferred).</li>\n<li>10+ years of experience in clinical operations, with a strong track record in oncology and/or inflammatory diseases.</li>\n<li>Experience leading operational aspects of early-phase clinical trials in the biotech or pharmaceutical industry.</li>\n<li>Demonstrated ability to build and lead teams in a dynamic, startup environment.</li>\n<li>In-depth knowledge of ICH-GCP guidelines, FDA/EMA regulations, and global clinical trial processes.</li>\n<li>Proven experience in vendor management, CRO oversight, budget management, and trial risk management.</li>\n<li>Experience in clinical site-side sample management and biomarker program support.</li>\n<li>Familiarity with data management principles and data quality oversight in clinical trials.</li>\n<li>Experience managing the generation of clinical documents across the trial lifecycle.</li>\n<li>Exceptional communication, leadership, and problem-solving skills.</li>\n<li>Experience in oncology, inflammatory diseases, and/or molecularly targeted therapies.</li>\n</ul>\n<h3>Benefits</h3>\n<p>The salary estimated for this position is $275,000 - $295,000 + bonus + options + benefits. Compensation will vary depending on job-related knowledge, skills, and experience. Actual compensation will be confirmed in writing at the time of the offer.</p>\n<p>What BigHat Offers:</p>\n<ul>\n<li>Range of health insurance plan options through Anthem and Kaiser (monthly credit if benefit waived)</li>\n<li>Dental, and vision coverage through Guardian</li>\n<li>Additional well-being benefits through Nayya, OneMedical, Wagmo, Rula, and more</li>\n<li>401(k) with company match</li>\n<li>DTO, two weeks of company-wide shutdown, and 12 company holidays</li>\n<li>Paid parental leave</li>\n</ul>","enriched_at":1784383437122},{"id":"job_86fcb5cf-e09","title":"Research Associate I, Platform Reagents & Assay Support","source_url":"https://bighatbiosciences.pinpointhq.com/en/postings/80aadf6d-0748-4fe4-976b-f48e558b21ea","location":"San Mateo, CA","job_type":"full time","experience_level":"entry","work_arrangement":"onsite","category":"Laboratory","description":"<p>BigHat Biosciences is seeking a self-motivated individual for a Research Associate I, Platform Reagents &amp; Assay Support (PRAS), role to power its in-house reagent manufacturing and QC efforts.</p>\n<h3>Key Responsibilities</h3>\n<ul>\n<li>Execute automated and manual high-throughput reagent manufacturing and QC workflows to support data generation across BigHat&#39;s production assay suite.</li>\n<li>Maintain detailed records of all reagent lot manufacturing and QC events using BigHat&#39;s documentation tools, and clearly communicate results and challenges.</li>\n<li>Contribute to reagent lot performance monitoring, and assist with troubleshooting efforts as needed.</li>\n<li>Collaborate on creating laboratory standard operating procedures (SOPs) for reagent manufacturing and QC.</li>\n<li>Work closely with BigHat team members to identify, design, and implement critical process and operational improvements to workflows and laboratory systems.</li>\n<li>Operate automated liquid handlers and analytical instruments to ensure efficient lab and platform operations.</li>\n</ul>\n<h3>Skills, Knowledge &amp; Expertise</h3>\n<ul>\n<li>BS in Biology or Chemistry, with 1+ year of industry experience.</li>\n<li>Experience in reagent manufacturing and quality control, process execution, and troubleshooting.</li>\n<li>Hands-on experience with automated liquid handlers (e.g., Hamilton, OpenTrons, Tecan, Agilent systems) and LIMS (nice-to-have).</li>\n<li>Familiarity with molecular biology techniques and general lab practices.</li>\n<li>Efficient time management and ability to work on multiple projects simultaneously in a dynamic start-up environment.</li>\n<li>Strong interpersonal skills and effective communication with multidisciplinary team members.</li>\n<li>Excellent record-keeping abilities for documenting experimental work and analytical data.</li>\n<li>Previous experience with barcoding systems, automated tube/plate labelers, inventory tracking, and Google Workspace tools (nice-to-haves).</li>\n</ul>\n<h3>Benefits</h3>\n<ul>\n<li>Salary estimated at $75,000 - $88,000 + bonus + options + benefits.</li>\n<li>Range of health insurance plan options through Anthem and Kaiser (monthly credit if benefit waived).</li>\n<li>Dental and vision coverage through Guardian.</li>\n<li>Additional well-being benefits through Nayya, OneMedical, Wagmo, Rula, and more.</li>\n<li>401(k) with company match.</li>\n<li>DTO, two weeks of company-wide shutdown, and 12 company holidays.</li>\n<li>Paid parental leave.</li>\n</ul>","enriched_at":1784027511156},{"id":"job_dcb2e4d3-a98","title":"Senior Software Engineer","source_url":"https://bighatbiosciences.pinpointhq.com/en/postings/3d8a673c-ce70-4d47-8175-2439a0b75061","location":"San Mateo, CA","job_type":"full time","experience_level":"senior","work_arrangement":"hybrid","category":"Engineering","description":"<p>BigHat Biosciences is looking for a Senior Software Engineer to join their engineering team. This role involves owning a significant area of their platform, leading epics end-to-end, and shaping the architecture and engineering practices.</p>\n<p>The ideal candidate will have 7+ years of professional software engineering experience building and owning production systems, or 5+ years of experience with prior experience in biotech, life sciences, laboratory environments, or scientific software.</p>\n<p>Key Responsibilities:</p>\n<ul>\n<li>Lead projects end-to-end, from PRD through implementation, testing, release, and validation against the customer success metric.</li>\n<li>Own one or more major areas of BigHat&#39;s internally developed, cloud-based platform as a subject-matter expert.</li>\n<li>Take on net-new, 0-to-1 work from specification, designing interactions between features and the infrastructure that supports them.</li>\n<li>Collaborate with scientists and product owners to translate real-world lab workflows into reliable software.</li>\n<li>Operate and run engineering processes, including PRD reviews, stand-ups, PR approvals, and other team ceremonies.</li>\n<li>Own the quality and outcomes of your work and your epics, including debugging, test failures, and production issues.</li>\n<li>Drive technical depth across the codebase, infrastructure, and systems, and actively improve the design and architectural principles the team works within.</li>\n<li>Design and build high-quality software across front-end (UI/UX) and back-end systems.</li>\n<li>Lead and review technical designs and PRDs; contribute architectural direction and surface risks and tradeoffs early.</li>\n<li>Write, maintain, and raise the bar on automated testing to ensure correctness, reliability, and maintainability.</li>\n<li>Run code reviews as a routine approver, providing thoughtful, high-leverage feedback that develops other engineers.</li>\n<li>Diagnose and resolve complex issues across production and development environments.</li>\n<li>Improve internal engineering practices, documentation, tooling, and architecture.</li>\n</ul>\n<p>Benefits:</p>\n<ul>\n<li>Salary estimated for this position is $198,000 - $215,000 + bonus + options + benefits.</li>\n<li>Range of health insurance plan options through Anthem and Kaiser.</li>\n<li>Dental, and vision coverage through Guardian.</li>\n<li>Additional well-being benefits through Nayya, OneMedical, Wagmo, Rula, and more.</li>\n<li>401(k) with company match.</li>\n<li>DTO, two weeks of company-wide shutdown, and 12 company holidays.</li>\n<li>Paid parental leave.</li>\n</ul>","enriched_at":1782353838680},{"id":"job_cdffb730-d6b","title":"Research Associate I, CFPS Production","source_url":"https://bighatbiosciences.pinpointhq.com/en/postings/26224083-090e-4ce8-8d61-c09ab4ab7a38","location":"San Mateo, CA","job_type":"full time","experience_level":"entry","work_arrangement":"onsite","category":"Lab Science","description":"<p>BigHat Biosciences is seeking a self-motivated individual for a Research Associate, CFPS Production role to manufacture, validate and execute experiments to develop cell-free protein synthesis (CFPS) reagents for BigHat’s high-throughput, automated platform for producing and characterizing antibodies.</p>\n<h3>Key Responsibilities</h3>\n<ul>\n<li>Manufacture and validate CFPS reagents used in BigHat’s high-throughput antibody screening platform including making buffers, media for biomass production and performing QC experiments on reagents.</li>\n<li>Maintain CFPS reagent manufacturing equipment including incubators, centrifuges, and homogenizers.</li>\n<li>Coordinate with lab ops team to request/order supplies for CFPS reagent manufacturing to ensure reliable stock for platform.</li>\n<li>Design and run experiments for development of next generation CFPS extract to optimize yield and purity of next generation antibodies on our platform.</li>\n<li>Keep a detailed record of all experiments using BigHat’s documentation tools, and clearly communicate results and challenges.</li>\n<li>Present experimental plans and results during regular meetings with manager and science teams.</li>\n</ul>\n<h3>Skills, Knowledge &amp; Expertise</h3>\n<ul>\n<li>B.S. degree in Biochemistry, Molecular Biology, or related field with 1-2 years of industry experience.</li>\n<li>Experience working with recombinant protein expression from bacterial cultures. Experience with CFPS is highly desired but not required.</li>\n<li>Experience with molecular cloning techniques including primer design, PCR, mutagenesis, Golden Gate Assembly.</li>\n<li>Preferred: Experience and knowledge of protein purification methods including affinity chromatography and SEC.</li>\n<li>Excellent communication skills; organized and works well in small groups.</li>\n<li>Experience with quantitative and/or statistical analysis software is a plus (e.g. Excel, GraphPad Prism, Python, R, etc.)</li>\n<li>Experience with automation and high-throughput tools and robotic instrumentation is a plus.</li>\n</ul>\n<h3>Benefits</h3>\n<p>The salary estimated for this position is $75,000 - $88,000 + bonus + options + benefits. Compensation will vary depending on job-related knowledge, skills, and experience. Actual compensation will be confirmed in writing at the time of the offer.</p>\n<p>What BigHat Offers:</p>\n<ul>\n<li>Range of health insurance plan options through Anthem and Kaiser (monthly credit if benefit waived)</li>\n<li>Dental, and vision coverage through Guardian</li>\n<li>Additional well-being benefits through Nayya, OneMedical, Wagmo, Rula, and more</li>\n<li>401(k) with company match</li>\n<li>DTO, two weeks of company-wide shutdown, and 12 company holidays</li>\n<li>Paid parental leave</li>\n</ul>","enriched_at":1781789340816},{"id":"job_54ec5545-771","title":"Scientist II, Developability","source_url":"https://bighatbiosciences.pinpointhq.com/en/postings/da57d3d6-24a9-4df8-857e-2e0fb6ce2205","location":"San Mateo, CA","job_type":"full time","experience_level":"senior","work_arrangement":"onsite","category":"Lab Science","description":"<p>BigHat Biosciences is seeking a hands-on Scientist II, Developability to drive antibody developability assessments. You will spend most of your time at the bench executing and innovating on developability workflows.</p>\n<h4>Key Responsibilities</h4>\n<ul>\n<li>Design, optimize, and execute high-throughput developability assays to expand BigHat&#39;s toolkit.</li>\n<li>Drive developability assessments across programs, focusing on data interpretation and organization.</li>\n<li>Support late-stage characterization and IND-enabling studies, including formulation screening and simulated administration studies.</li>\n<li>Serve as the Developability lead within project teams, guiding experimental strategy.</li>\n<li>Work cross-functionally to automate methods, train colleagues, and adapt workflows to existing LIMS infrastructure.</li>\n<li>Analyze data, interpret scientific findings, and propose next steps.</li>\n</ul>\n<h4>Skills, Knowledge &amp; Expertise</h4>\n<ul>\n<li>PhD in Biochemistry or a relevant discipline with 3+ years of industry experience.</li>\n<li>Strong background in biophysical and analytical characterization of antibodies and antibody fragments.</li>\n<li>Experience with protein structures and antibody engineering.</li>\n<li>Track record of translating complex data into clear results and recommended actions.</li>\n<li>Enthusiastic about learning and onboarding new technologies.</li>\n</ul>\n<h4>Benefits</h4>\n<ul>\n<li>Salary estimated at $145,000 - $165,000 + bonus + options + benefits.</li>\n<li>Range of health insurance plan options.</li>\n<li>Dental and vision coverage.</li>\n<li>Additional well-being benefits.</li>\n<li>401(k) with company match.</li>\n<li>DTO, two weeks of company-wide shutdown, and 12 company holidays.</li>\n<li>Paid parental leave.</li>\n</ul>","enriched_at":1781789117376},{"id":"job_cf1d9a09-3b3","title":"Associate Scientist, Display Technologies","source_url":"https://bighatbiosciences.pinpointhq.com/en/postings/3167efbf-ec44-4115-823c-53afd3fefdb5","location":"San Mateo, CA","job_type":"full time","experience_level":"mid","work_arrangement":"onsite","category":"Engineering","description":"<p>The role: We are seeking a curious and motivated Associate Scientist to join the Display Technologies team. This individual will contribute to our antibody discovery and engineering efforts and help generate high-quality data to improve our machine learning models using display technologies, working closely with senior scientists and cross-functional teams.</p>\n<p>Key Responsibilities:</p>\n<p>Support R&amp;D projects advancing display technologies at BigHat that expands our antibody discovery capabilities and feed our ML models.</p>\n<p>Lead in the construction and QC of phage and yeast display libraries across diverse antibody formats (VHH, scFv, Fab) using standard molecular biology techniques (PCR, molecular cloning, electroporation).</p>\n<p>Execute phage and yeast display selections using naive and affinity and stability maturation libraries to discover and engineer antibodies with desired therapeutic properties.</p>\n<p>Express, purify, and characterize display-derived molecules using assays including ELISA, flow cytometry, BLI/SPR, CE-SDS, and others.</p>\n<p>Analyse selection results and contribute to discussions on next steps and future experimental design.</p>\n<p>Collaborate with our Data Science and Machine Learning teams to inform library design and interpret selection data for model training.</p>\n<p>Present experimental plans and results during regular meetings with manager and science teams.</p>\n<p>Maintain thorough records using LIMS and electronic notebooks.</p>\n<p>Benefits: The salary estimated for this position is $120,000 - $135,000 + bonus + options + benefits. Compensation will vary depending on job-related knowledge, skills, and experience. Actual compensation will be confirmed in writing at the time of the offer.</p>\n<p>What BigHat Offers:</p>\n<p>Range of health insurance plan options through Anthem and Kaiser (monthly credit if benefit waived)</p>\n<p>Dental, and vision coverage through Guardian</p>\n<p>Additional well-being benefits through Nayya, OneMedical, Wagmo, Rula, and more</p>\n<p>401(k) with company match</p>\n<p>DTO, two weeks of company-wide shutdown, and 12 company holidays</p>\n<p>Paid parental leave</p>","enriched_at":1781118554574}],"category_normalised":[{"category":"it","count":2},{"category":"engineering","count":2},{"category":"operations","count":1}],"velocity":{"weeks":[{"week_start":"2026-06-01","count":1},{"week_start":"2026-06-08","count":1},{"week_start":"2026-06-15","count":2},{"week_start":"2026-06-22","count":1},{"week_start":"2026-07-13","count":2},{"week_start":"2026-08-03","count":2},{"week_start":"2026-08-10","count":2}],"trend":"stable","wow_pct":0},"momentum":{"recent_14d":4,"prior_14d":0,"growth_pct":0,"classification":"stable"},"salary_vs_industry":{"company_median":163750,"industry_median":null,"percentile":null,"sample_size":10,"by_region":[{"region":"United States","company_median":163750,"industry_median":null,"sample":10}],"transparency_pct":91,"industry_transparency_pct":0,"transparency_warning":false},"market_share":{"company_jobs":11,"industry_total":11,"share_pct":100,"rank":1,"peer_count":1},"ai_exposure":{"occupation_weighted_score":0.273,"skill_weighted_score":0,"top_exposed_titles":[],"top_exposed_skills":[]},"peer_set":[],"skills_lq":[],"geographic_shift":{"current":[{"region":"United States","count":11,"share_pct":100}],"emerging":[],"shrinking":[]},"seniority_anomalies":{"exec_recent_30d":2,"exec_prior_90d_avg":0,"exec_growth_pct":100,"notable_exec_hires":[{"title":"Director, Antibody Discovery","location":"San Mateo, CA","posted_at":"2026-08-08"},{"title":"Senior Director, Clinical Operations","location":"San Mateo, CA","posted_at":"2026-07-18"}]},"posting_dynamics":{"median_days_open":90,"industry_median_days_open":null,"long_open_count":0,"closure_rate_pct":8}}}}